The diagnosis and management of allergic reactions in patients sensitized to non?specific lipid transfer proteins

Sensitization to one or more non-specific lipid transfer proteins (nsLTPs), initially thought exist mainly in southern Europe, is becoming accepted as a cause of allergic reactions plant foods across Europe and beyond. The peach nsLTP allergen Pru p 3 dominant sensitizing peaches common food trigger, although multiple can be involved. A frequent feature the requirement for cofactor (exercise, alcohol, non-steroidal anti-inflammatory drugs, Cannabis sativa) present elicit reaction. variability triggers makes it essential include an allergy-focused diet clinical history diagnostic workup. Testing on suspected should also establish whether sensitization present, using purified recombinant allergens such 3. avoidance known trigger advice cofactors currently main management this condition. Studies immunotherapy are promising, but unknown treatments will useful populations where not primary allergen. Future research focus mechanisms cofactors, improving accuracy establishing efficacy immunotherapy.